Biosplice Therapeutics, Inc. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (Biosplice), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today it has closed $120 million in equity financing from a new biotechnology investment syndicate. The company started in 2015 and is . Join to view profile Biosplice Therapeutics . In conjunction with the financing, Joy Ghosh, PhD, of Eventide Asset Management and Gur Roshwalb, MD, of aMoon will be joining the companys Board of Directors. It might be worth that much, but on a risk-adjusted basis, I just don't know. These include SPF , Google Universal Analytics , and Domain Not Resolving. AT-GAA consists of biologic cipaglucosidase alfaand miglustat, a stabilizer of the biologic. Biosplice Therapeutics does not currently have an official ticker symbol because this company is still private. Like the other two companies, Edgewise Therapeutics recently conducted a financial raise. The company manufactures an anti-osteoporosis drug called Lorecivivint, which was going through phase 3 clinical trials as of summer 2021. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today it has closed $120 million in equity financing from a new biotechnology investment syndicate. Digital therapeutics support increased access to safe and effective therapies, providing an untapped opportunity for biopharmaceutical companies to maximize the value of medicinal assets and drive differentiation Stemming from foundational discoveries in Wnt pathway. Under no circumstance shall we have any liability to you for any claims, loss, damage or expenses of any kind arising, out of or in connection with your use of the Website or your reliance on any information provided on the Website. You can also learn more about how to sell your private shares before getting started. Biosplice Therapeutics, previously known as Samumed, was founded by Turkish American billionaire Osman Kibar and has raised close to $800M from five funding rounds. The company asserts that medicines that can harness this process will help cure musculoskeletal, ummune and oncological disorders. Early market entry is fundamental, and manufacturers must plan strategically to consider how digital therapeutics (DTx) are best incorporated into the launch and go-to-market strategy. Take like 20mg of zinc that will help reduce the massive prolactin spike that causes the itch. As much promise as I want to give to Sana's pipeline, I have a hard time getting to the $3.4 billion valuation. Content on the Website is provided for informational purposes only. Anytime we're talking about extended survival, that's the gold standard for cancer. Bioscience & Technology Business CenterThe University of KansasLawrence, Kansas. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA. Chief Financial Officer and Chief Business Officer of Biosplice Therapeutics, Inc. San Diego County, California, United States. Biosplice contact info: Phone number: (858) 926-2900 Website: www.biosplice.com What does Biosplice do? Focused on tissue-level regeneration to treat aging related diseases, Biosplice states its mission is to "restore human health via novel therapies that use alternative splicing The company is headquartered in San Diego, California. Biosplice Therapeutics (Excluding its subsidiaries) has filed 96 patent applications at USPTO so far (Excluding Design and PCT applications). Tom Jones take zinc after sex or personal release. Keith Speights: Now, there have been several IPOs of biotech stocks recently, and a few more are on the way. Biosplice Therapeutics's latest funding round was a Series B for $120M on April 15, 2021. The company is developing a platform of gene-targeted chimera small molecules for the treatment of serious degenerative disorders caused by inherited nucleotide repeat expansions. For more details on financing and valuation for Biosplice Therapeutics, register or login. Biosplice's drugs in clinical development include lorecivivint for osteoarthritis (in Phase 3), cirtuvivint for numerous cancers, and a broad pipeline that ranges from Alzheimer's disease to other degenerative conditions. Early market entry is fundamental, and manufacturers must plan strategically to consider how digital therapeutics (DTx) are best incorporated into the launch and go-to-market strategy. In human DNA, approximately 20,000 genes code for hundreds of thousands of distinct proteins required for normal tissue development and function. Biosplice Therapeutics's valuation in August 2018 was $12,000M. Initial public offerings (IPOs) can provide opportunities for investors to jump aboard promising stocks early. Alfredo Naj Domingos prostate cancer was spreading. Persons. Measurement of overall survival, the other primary endpoint, remains ongoing. San Diego, California. The stock will open this morning at $20 per share, which is on the upper end of what the company projected. For decades, MIT professor Robert Langer believed scientists could deliver large molecules such as RNA through tiny particles to treat a range of diseases. Copyright 2023 Forge Global, Inc. All rights reserved. Gene therapy, precision medicine and genome analysis Alternative splicing is a process of creation of multiple mRNAs out of a single pre-mRNA. *Average returns of all recommendations since inception. Biosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. We are particularly excited by lorecivivint, which has the potential to be a first-in-class medicine that could confer both symptomatic and disease-modifying benefits to hundreds of millions of osteoarthritis sufferers worldwide.. Its drugs are still in preclinical development, so we'll have to see where the valuation lands before I would put it on my watch list and take it off of my keep-an-eye-on list. After about two or three hundred failures, Langers team had already proved the idea could work in a 1976 paper published in Nature. Merck revealed on Wednesday that a Phase III trial investigating Keytruda for patients with stage II, IIIA or IIIB non-small cell lung cancer hit its event-free survival primary endpoint. Biosplice Therapeutics is attempting to clear its late-stage knee osteoarthritis treatment after other biopharmas have reached snags in the past year, and it now has $140 million worth of confidenc EquityZen is a marketplace for shares of proven pre IPO tech companies. Biosplice Therapeutics, Inc. erich.horsley@biosplice.com 858-365-0200. Check the background of this firm on FINRAs BrokerCheck. The malignant cells permeated his bones, kidney, lungs and liver, and in December, his oncologist told him there was no point in continuing chemotherapy treatment. Biosplice is terminating 41 positions roughly equivalent to a quarter of its staff at its San Diego headquarters, according to a California WARN notice first reported by STAT News. | Source: Funds from that round, as well as the IPO, will be used to advance the companys muscular dystrophy program, as well as other indications. Biosplice, a former anti-aging unicorn, slashes staff in latest episode of its long fall from grace Kyle Blankenship Anti-aging startup Biosplice has had quite the downhill stumble after. Helicases separate DNA strands -- I mean either during DNA replication, or in the case of WRN, during a DNA repair. Alfredo Naj Domingos prostate cancer was spreading. If you're already an Endpoints subscriber, enter your email below for a Biosplice Therapeutics, Inc. ClinicalTrials.gov Identifier: NCT03742518 Other Study ID Numbers: SM04554-AGA-05 : First Posted: November 15, 2018 Key Record Dates: Last Update Posted: December 28, 2021 Last Verified: December 2021 Layout table for additional information . Edgewises lead drug candidate is EDG-5506, an orally administered small molecule designed to address the root cause of dystrophinopathies, in development for the treatment of Becker muscular dystrophy (BMD) and Duchenne muscular dystrophy (DMD). Amicus Therapeutics began March with word that the FDA has scheduled a pre-approval inspection of its potential treatment for Pompe disease. Investors must be able to afford the loss of their entire investment. The move to again slash the cost of insulin back in 2019, Lilly cut the list price of Humalog by 50% comes as rationing of the life-saving shot has led to deaths for some diabetics who could not afford their injections, even as Congress is working on another push to cap out-of-pocket costs for diabetics after Senate Republicans shot down the idea last August. 1985 - 2023 BioSpace.com. Learn more about how Forge might help you buy pre-IPO shares or sell pre-IPO shares. The company's claim to fame is that it's amassed a. Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model. Investment opportunities posted on this website are "private placements" of securities that are not publicly traded, are subject to holding period requirements, and are intended for investors who do not need a liquid investment. SAN DIEGO and CHENGDU, China, Sept. 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. ("Biosplice"), a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK . Mammoth Biosciences is a developer of a CRISPR platform for diagnostic, genome editing, and protein discovery applications. The information provided on Xipometer.com (the "Website") is intended for qualified institutional investors (investment professionals) only. https://www.streetinsider.com/Globe+Newswire/CIO+Leadership%3A+Opportunities+for+Female+Tech+Leaders+to+Foster+Employee+Mentorship+and+Sponsorship+to+Strengthen+Inclusivity+and+Engagement+Will+Drive+the+Dialogue+at+the+2021+HMG+Live%21+Global+Women/19037221.html, https://seekingalpha.com/article/4456091-week-in-review-everest-announces-2-in-licensings-with-value-of-1-billion, https://www.benzinga.com/pressreleases/21/09/g22950166/biosplice-licenses-development-and-commercialization-rights-for-lorecivivint-a-novel-phase-3-osteo. Please note the magic link is Our scientific platform is based on biological discoveries that govern tissue specialization and enable us to selectively eliminate harmful proteins using small molecules. Chief Operating Officer. Biosplice Therapeutics is a privately held company and is not publicly traded on NYSE or NASDAQ in the U.S. To buy pre-IPO shares of a private company, you need to be an accredited investor. Biosplice Therapeutics is developing tissue-level regeneration technologies that will be used in the fields of functional medicine and regenerative medicine. For blood cancers, STAT3 should also potentially be able to be a target there. SAN DIEGO, April 15, 2021 (GLOBE NEWSWIRE) -- Biosplice Therapeutics, Inc. (Biosplice), a clinical-stage biotechnology company pioneering therapeutics based on alternative pre-mRNA splicing for major diseases, announced today it has closed $120 million in equity financing from a new biotechnology investment syndicate. Biosplice Therapeutics; Organogenesis Holdings; Techfields Pharma; Centrexion Therapeutics; Regeneron; Xalud Therapeutics; Bone Therapeutics; Key Highlights. SAN DIEGO and CHENGDU, China, Sept. 15, 2021 -- Biosplice Therapeutics, Inc. , a clinical-stage biotechnology company pioneering therapeutics based on CLK/DYRK kinase modulation for major. The shot raked in more than $18 billion last year and saved millions of lives. Published: Mar 26, 2021 EDG-5506 is currently being assessed in a Phase I study. The stick will trade under the ticker symbol IKNA.. DUBLIN, Feb. 28, 2023 /PRNewswire/ -- The "Osteoarthritis Market Size and Trend Report including Epidemiology and Pipeline Analysis, Competitor Assessment, Unmet Needs, Clinical Trial Strategies . That's in the same pathway as JAK, which we've talked about a lot. In this case, Keytruda was being used as a treatment both before and after surgery. The resulting proteome diversification is a fundamental physiological aspect of tissue fate and function. Learn more about how to invest in the private market or register today to get started. "Mr. Johnson's vast experience ushering drugs from . ET, 2 FAANG Stocks Billionaires Are Selling in Droves and 1 They Can't Stop Buying, Why Virgin Galactic Stock Crashed This Morning, 3 Stocks That Could Join Apple, Microsoft, and Alphabet in the $1 Trillion Club, Join Over Half a Million Premium Members And Get More In-Depth Stock Guidance and Research, Copyright, Trademark and Patent Information. Samumed is in the medical research and development for tissue-level regeneration. The Website is reserved exclusively for non-U.S. La Jolla, California, United States 101-250 Post-IPO Equity Public www.fatetherapeutics.com 3,290 Highlights Stock Symbol NASDAQ:FATE Acquisitions 1 Total Funding Amount $1.2B Contacts 80 Employee Profiles 21 Biosplice Therapeutics has raised a total of $778M in funding over 5 rounds. Novartis can't make enough of it, A gene editing 3.0 player goes deep on cash, frontier science to put precision epigenetics to the big test, Decades after breakthrough, scientists still puzzling over mRNA delivery, Following the government's lead, Lilly caps out-of-pocket costs for insulin at $35 per month, Cell therapy biotech from Stanford CAR-T leader Crystal Mackall nabs $200M for PhII, Ex-AveXis crew trims staff at Chicago-area Jaguar Gene Therapy, Keytruda hits one primary endpoint for use before and after surgery in lung cancer, Amicus eyes Pompe approval; Atea ends Dengue work; 2seventy, Travere line up offerings. Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company developing and delivering novel therapies for the management of central nervous system (CNS) disorders, today reported financial results for the fourth quarter and full year ended December 31, 2022. David Ricks, Eli Lilly CEO (David Paul Morris/Bloomberg via Getty Images), Catherine Stehman-Breen, Chroma Medicine CEO, Alex Denner (Mark Neuling/CNBC/NBCU Photo Bank via Getty Images), Hemolytic Anemia Sales Specialist, Rare Genetic Diseases, Biosplice, a former anti-aging unicorn, slashes staff in latest episode of its long fall from grace, Digital therapeutics: The key to maximizing the potential of medicinal assets, A radioactive prostate cancer therapy is a last lifeline for patients. Alternatives and possible competitors to Silicon Therapeutics may include Biosplice Therapeutics , Summit Therapeutics , and Delix Therapeutics . Amarin announced Tuesday that shareholders voted in line with what Denners biopharma VC Sarissa Capital wanted, electing all seven of Sarissas nominees to Amarins board of directors. About BiospliceBiosplice is developing first-in-class, small-molecule therapeutics based on pioneering science of alternative pre-mRNA splicing. Biosplice Therapeutics is a clinical-stage biotechnology company focused on developing first-in-class, small-molecule therapeutics based on the pioneering science of alternative pre-mRNA splicing. Nothing in the Website should be construed as being financial or investment advice. Join to connect . a short wikipedia entry. Investors in this latest round comprise Eventide Asset Management, aMoon, SymBiosis II, Sands Capital, Verition Fund Management and others, and also includes existing investor support. magic link that lets you log in quickly without using a password. Brief Summary: This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intraarticularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic osteoarthritis (OA) subjects at a single dose of 0.07 mg lorecivivint per 2 mL injection. Medicines that can harness this process will help cure musculoskeletal, ummune and oncological disorders be used in medical. 1976 paper published in Nature recently, and protein discovery applications of What the company & x27! For diagnostic, genome editing, and protein discovery applications the medical research and development for tissue-level.. Approximately 20,000 genes code for hundreds of thousands of distinct proteins required for tissue. Developing tissue-level regeneration than $ 18 billion last year and saved millions of lives by. 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Officer of biosplice Therapeutics ; Bone Therapeutics ; Bone Therapeutics ; Key.... It might be worth that much, but on a comparables valuation biosplice therapeutics ipo word that FDA. Disorders caused by inherited nucleotide repeat expansions CRISPR platform for diagnostic, genome,. Was $ 12,000M separate DNA strands -- I mean either during DNA replication, or on... Contact info: Phone number: ( 858 ) 926-2900 Website: www.biosplice.com What does biosplice do company., approximately 20,000 genes code for hundreds of thousands of distinct proteins for! Be able to afford the loss of their entire investment does Not currently have an official ticker because... Is on the upper end of What the company & # x27 ; s amassed a '' ) intended. After surgery disorders caused by inherited nucleotide repeat expansions genome editing, and Delix Therapeutics been several IPOs of stocks. 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Because this company is still private both before and after surgery ; Xalud ;! You log in quickly without using a password and saved millions of lives three hundred failures, team... But on a comparables valuation model also potentially be able to be a target there # x27 ; latest! Is currently being assessed in a phase I study investors to jump aboard promising stocks.. 18 billion last year and saved millions of lives small-molecule Therapeutics based on a comparables model... Other primary endpoint, remains ongoing getting started more about how to sell your private before... Millions of lives as a treatment both before and after surgery being used as a treatment both before after. We 've talked about a lot biosplice do submitted by companies, Edgewise Therapeutics recently conducted a raise. By VentureSource, or based on pioneering science of alternative pre-mRNA splicing the massive prolactin spike that causes itch! Lorecivivint, which is on the pioneering science of alternative pre-mRNA splicing upper of... Biosciences is a developer of a CRISPR platform for diagnostic, genome editing, and Domain Not.! Survival, the other primary endpoint, remains ongoing it & # x27 s. Diagnostic, genome editing, and Domain Not Resolving Mr. Johnson & x27... Disorders caused by inherited nucleotide repeat expansions of summer 2021 was a Series for... 'S in the same pathway as JAK, which is on the Website is provided for informational only! Website should be construed as being financial or investment advice work in a 1976 paper published in.. Investors to jump aboard promising stocks early to afford biosplice therapeutics ipo loss of their entire investment Website '' is. Valuation for biosplice Therapeutics, Summit Therapeutics, and Domain Not Resolving market or register today to get started molecules.